Speedily attain sections as skinny or thick as your application requires, with out worrying about shedding or distorting precious tissue samples.
Our switch-critical SmartBatch+ procedure combines electrophoretic tissue clearing and immunolabeling into one higher-throughput unit.
Antibodies may well acquire weeks to diffuse via only a few millimeters of tissue, having a steep labeling gradient from surface area to core.
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SE employs a rotational electrical area to disperse extremely electromobile molecules (such as antibodies or surfactant micelles) all over a porous sample without the need of detrimental electrically billed constructions within the tissue. This enables two-four day clearing of intact organs,
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Megatome is a novel microtome that enables for high-precision sectioning of a variety of tissue samples – from organoids, to arrays of animal organs, to intact human brain hemispheres megatomi.com – with minimal tissue problems and information decline.
eFLASH is actually a rapid tissue labeling procedure that permits for uniform entire-organ staining in twenty rounds of labeling.
The SmartSPIM mild sheet microscope presents unparalleled resolution and acquisition pace throughout intact tissue volumes, even though its modular design means that you can upgrade and personalize person parts.
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Protect avoids the variability of hydrogel embedding and the information decline from PFA preservation, defending specimens for many rounds of processing.
Leverage the Distinct+ tissue clearing strategy, in conjunction with eFLASH and patented stochastic electrotransport technologies, to quickly obvious and label total organs. Crucial highlights and characteristics involve:
Our novel SHIELD tissue preservation approach kinds intramolecular bonds working with polyfunctional, adaptable epoxides to stabilize tissue architecture and safeguard the sample’s endogenous fluorescence, protein antigenicity and nucleic acids.